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Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors.
In a population-based, matched case-control study from southern Sweden of 400 patients with a first diagnosis of malignant melanoma and 640 healthy control subjects aged 15-75 years, the association between commonly prescribed drugs, alcohol, smoking and malignant melanoma was evaluated. In addition...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1996
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074414/ https://www.ncbi.nlm.nih.gov/pubmed/8624275 |
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author | Westerdahl, J. Olsson, H. Måsbäck, A. Ingvar, C. Jonsson, N. |
author_facet | Westerdahl, J. Olsson, H. Måsbäck, A. Ingvar, C. Jonsson, N. |
author_sort | Westerdahl, J. |
collection | PubMed |
description | In a population-based, matched case-control study from southern Sweden of 400 patients with a first diagnosis of malignant melanoma and 640 healthy control subjects aged 15-75 years, the association between commonly prescribed drugs, alcohol, smoking and malignant melanoma was evaluated. In addition, the relation between reproductive and hormonal factors and melanoma in women was studied. It was found that certain specific types of prescribed drugs, i.e. beta-blockers, hydralazines and benzodiazepines, may increase the risk of melanoma development. However, these associations were diminished, at least for benzodiazepines, after controlling for host factors. As these findings are unconfirmed, and may be due to chance or confounding, further studies are warranted. The risk of malignant melanoma was not influenced by alcohol consumption or smoking habits. Our results do not suggest an association between oral contraceptives and melanoma. Furthermore, reproductive factors were not independent risk factors for melanoma. However, increasing number of live births seemed to be protective (P for trend = 0.01). There is a need for further research to be able to draw firm conclusions on the relation between number of live births and melanoma. The results based on histopathological re-examinations and those based on tumour registry data were essentially the same. |
format | Text |
id | pubmed-2074414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20744142009-09-10 Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. Westerdahl, J. Olsson, H. Måsbäck, A. Ingvar, C. Jonsson, N. Br J Cancer Research Article In a population-based, matched case-control study from southern Sweden of 400 patients with a first diagnosis of malignant melanoma and 640 healthy control subjects aged 15-75 years, the association between commonly prescribed drugs, alcohol, smoking and malignant melanoma was evaluated. In addition, the relation between reproductive and hormonal factors and melanoma in women was studied. It was found that certain specific types of prescribed drugs, i.e. beta-blockers, hydralazines and benzodiazepines, may increase the risk of melanoma development. However, these associations were diminished, at least for benzodiazepines, after controlling for host factors. As these findings are unconfirmed, and may be due to chance or confounding, further studies are warranted. The risk of malignant melanoma was not influenced by alcohol consumption or smoking habits. Our results do not suggest an association between oral contraceptives and melanoma. Furthermore, reproductive factors were not independent risk factors for melanoma. However, increasing number of live births seemed to be protective (P for trend = 0.01). There is a need for further research to be able to draw firm conclusions on the relation between number of live births and melanoma. The results based on histopathological re-examinations and those based on tumour registry data were essentially the same. Nature Publishing Group 1996-05 /pmc/articles/PMC2074414/ /pubmed/8624275 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Westerdahl, J. Olsson, H. Måsbäck, A. Ingvar, C. Jonsson, N. Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title | Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title_full | Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title_fullStr | Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title_full_unstemmed | Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title_short | Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
title_sort | risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074414/ https://www.ncbi.nlm.nih.gov/pubmed/8624275 |
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