Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro.

Lometrexol (5,10-dideazatetrahydrofolic acid; DDATHF), is a specific inhibitor of glycinamideribonucleosyl (GAR) transformylase with anti-tumour activity in murine and human carcinomas. The cytotoxicity activity of DDATHF was evaluated in vitro in NIH/3T3 cells transfected with human alpha-folate-bi...

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Detalles Bibliográficos
Autores principales: Sen, S., Erba, E., D'Incalci, M., Bottero, F., Canevari, S., Tomassetti, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074460/
https://www.ncbi.nlm.nih.gov/pubmed/8595169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074460/
https://www.ncbi.nlm.nih.gov/pubmed/8595169

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