Deletion mapping on chromosome 1p in well-differentiated gastric cancer.

To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine mi...

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Autores principales: Ezaki, T., Yanagisawa, A., Ohta, K., Aiso, S., Watanabe, M., Hibi, T., Kato, Y., Nakajima, T., Ariyama, T., Inazawa, J., Nakamura, Y., Horii, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074468/
https://www.ncbi.nlm.nih.gov/pubmed/8595154
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author Ezaki, T.
Yanagisawa, A.
Ohta, K.
Aiso, S.
Watanabe, M.
Hibi, T.
Kato, Y.
Nakajima, T.
Ariyama, T.
Inazawa, J.
Nakamura, Y.
Horii, A.
author_facet Ezaki, T.
Yanagisawa, A.
Ohta, K.
Aiso, S.
Watanabe, M.
Hibi, T.
Kato, Y.
Nakajima, T.
Ariyama, T.
Inazawa, J.
Nakamura, Y.
Horii, A.
author_sort Ezaki, T.
collection PubMed
description To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine microsatellite markers. All tumours were informative with at least one locus; three revealed replication errors (RERs) at multiple microsatellite loci, and interstitial or telomeric allelic deletions were observed in 12 cases. Deletion mapping of these tumours defined a commonly deleted region between two loci, D1S201 and D1S197, that are 13 cM apart. As two loci within the commonly deleted region, D1S57 (pYNZ2) and D1S62 (pTHI54), were mapped respectively to 1p35 and 1p34.3 by fluorescence in situ hybridisation, we conclude that a locus likely to contain a tumour-suppressor gene for gastric cancer is located within a 13 cM region encompassing two chromosomal bands. IMAGES:
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spelling pubmed-20744682009-09-10 Deletion mapping on chromosome 1p in well-differentiated gastric cancer. Ezaki, T. Yanagisawa, A. Ohta, K. Aiso, S. Watanabe, M. Hibi, T. Kato, Y. Nakajima, T. Ariyama, T. Inazawa, J. Nakamura, Y. Horii, A. Br J Cancer Research Article To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine microsatellite markers. All tumours were informative with at least one locus; three revealed replication errors (RERs) at multiple microsatellite loci, and interstitial or telomeric allelic deletions were observed in 12 cases. Deletion mapping of these tumours defined a commonly deleted region between two loci, D1S201 and D1S197, that are 13 cM apart. As two loci within the commonly deleted region, D1S57 (pYNZ2) and D1S62 (pTHI54), were mapped respectively to 1p35 and 1p34.3 by fluorescence in situ hybridisation, we conclude that a locus likely to contain a tumour-suppressor gene for gastric cancer is located within a 13 cM region encompassing two chromosomal bands. IMAGES: Nature Publishing Group 1996-02 /pmc/articles/PMC2074468/ /pubmed/8595154 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ezaki, T.
Yanagisawa, A.
Ohta, K.
Aiso, S.
Watanabe, M.
Hibi, T.
Kato, Y.
Nakajima, T.
Ariyama, T.
Inazawa, J.
Nakamura, Y.
Horii, A.
Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title_full Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title_fullStr Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title_full_unstemmed Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title_short Deletion mapping on chromosome 1p in well-differentiated gastric cancer.
title_sort deletion mapping on chromosome 1p in well-differentiated gastric cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074468/
https://www.ncbi.nlm.nih.gov/pubmed/8595154
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