Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.

Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme...

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Autores principales: Eno-Amooquaye, E. A., Searle, F., Boden, J. A., Sharma, S. K., Burke, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074478/
https://www.ncbi.nlm.nih.gov/pubmed/8645574
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author Eno-Amooquaye, E. A.
Searle, F.
Boden, J. A.
Sharma, S. K.
Burke, P. J.
author_facet Eno-Amooquaye, E. A.
Searle, F.
Boden, J. A.
Sharma, S. K.
Burke, P. J.
author_sort Eno-Amooquaye, E. A.
collection PubMed
description Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme concentrations in normal tissue and blood demonstrate the fundamental requirement to remove or inactivate non-specifically held enzyme in this system.
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spelling pubmed-20744782009-09-10 Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol. Eno-Amooquaye, E. A. Searle, F. Boden, J. A. Sharma, S. K. Burke, P. J. Br J Cancer Research Article Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme concentrations in normal tissue and blood demonstrate the fundamental requirement to remove or inactivate non-specifically held enzyme in this system. Nature Publishing Group 1996-06 /pmc/articles/PMC2074478/ /pubmed/8645574 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Eno-Amooquaye, E. A.
Searle, F.
Boden, J. A.
Sharma, S. K.
Burke, P. J.
Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title_full Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title_fullStr Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title_full_unstemmed Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title_short Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
title_sort altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074478/
https://www.ncbi.nlm.nih.gov/pubmed/8645574
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