A non-random deletion in the p53 gene in oral squamous cell carcinoma.

In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tum...

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Autores principales: Nylander, K., Schildt, E. B., Eriksson, M., Magnusson, A., Mehle, C., Roos, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074479/
https://www.ncbi.nlm.nih.gov/pubmed/8645583
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author Nylander, K.
Schildt, E. B.
Eriksson, M.
Magnusson, A.
Mehle, C.
Roos, G.
author_facet Nylander, K.
Schildt, E. B.
Eriksson, M.
Magnusson, A.
Mehle, C.
Roos, G.
author_sort Nylander, K.
collection PubMed
description In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group. IMAGES:
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spelling pubmed-20744792009-09-10 A non-random deletion in the p53 gene in oral squamous cell carcinoma. Nylander, K. Schildt, E. B. Eriksson, M. Magnusson, A. Mehle, C. Roos, G. Br J Cancer Research Article In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group. IMAGES: Nature Publishing Group 1996-06 /pmc/articles/PMC2074479/ /pubmed/8645583 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nylander, K.
Schildt, E. B.
Eriksson, M.
Magnusson, A.
Mehle, C.
Roos, G.
A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title_full A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title_fullStr A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title_full_unstemmed A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title_short A non-random deletion in the p53 gene in oral squamous cell carcinoma.
title_sort non-random deletion in the p53 gene in oral squamous cell carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074479/
https://www.ncbi.nlm.nih.gov/pubmed/8645583
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