A pilot study on risk factors and p53 gene expression in colorectal cancer.

Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensi...

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Detalles Bibliográficos
Autores principales: Fredrikson, M., Axelson, O., Sun, X. F., Arbman, G., Nilsson, E., Nordenskjöld, B., Sjödahl, R., Söderkvist, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074496/
https://www.ncbi.nlm.nih.gov/pubmed/8645592
Descripción
Sumario:Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.

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