A pilot study on risk factors and p53 gene expression in colorectal cancer.

Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensi...

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Detalles Bibliográficos
Autores principales: Fredrikson, M., Axelson, O., Sun, X. F., Arbman, G., Nilsson, E., Nordenskjöld, B., Sjödahl, R., Söderkvist, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074496/
https://www.ncbi.nlm.nih.gov/pubmed/8645592
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author Fredrikson, M.
Axelson, O.
Sun, X. F.
Arbman, G.
Nilsson, E.
Nordenskjöld, B.
Sjödahl, R.
Söderkvist, P.
author_facet Fredrikson, M.
Axelson, O.
Sun, X. F.
Arbman, G.
Nilsson, E.
Nordenskjöld, B.
Sjödahl, R.
Söderkvist, P.
author_sort Fredrikson, M.
collection PubMed
description Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.
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spelling pubmed-20744962009-09-10 A pilot study on risk factors and p53 gene expression in colorectal cancer. Fredrikson, M. Axelson, O. Sun, X. F. Arbman, G. Nilsson, E. Nordenskjöld, B. Sjödahl, R. Söderkvist, P. Br J Cancer Research Article Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors. Nature Publishing Group 1996-06 /pmc/articles/PMC2074496/ /pubmed/8645592 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Fredrikson, M.
Axelson, O.
Sun, X. F.
Arbman, G.
Nilsson, E.
Nordenskjöld, B.
Sjödahl, R.
Söderkvist, P.
A pilot study on risk factors and p53 gene expression in colorectal cancer.
title A pilot study on risk factors and p53 gene expression in colorectal cancer.
title_full A pilot study on risk factors and p53 gene expression in colorectal cancer.
title_fullStr A pilot study on risk factors and p53 gene expression in colorectal cancer.
title_full_unstemmed A pilot study on risk factors and p53 gene expression in colorectal cancer.
title_short A pilot study on risk factors and p53 gene expression in colorectal cancer.
title_sort pilot study on risk factors and p53 gene expression in colorectal cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074496/
https://www.ncbi.nlm.nih.gov/pubmed/8645592
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