Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide.

Drug resistance to anti-tumour agents often coincides with mutations in the gene encoding DNA topoisomerase II alpha. To examine how inactive forms of topoisomerase II can influence resistance to the chemotherapeutic agent VP-16 (etoposide) in the presence of a wild-type allele, we have expressed po...

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Detalles Bibliográficos
Autores principales: Vassetzky, Y. S., Alghisi, G. C., Roberts, E., Gasser, S. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074512/
https://www.ncbi.nlm.nih.gov/pubmed/8630279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074512/
https://www.ncbi.nlm.nih.gov/pubmed/8630279

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