Cargando…

Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.

In 1983, we reported results from the Oxford Family Planning Association contraceptive study regarding the association between oral contraceptives (OCs) and cervical neoplasia, after a 10 year follow-up of a cohort of 17,000 women. Further findings from this study are reported here after an addition...

Descripción completa

Detalles Bibliográficos
Autores principales: Zondervan, K. T., Carpenter, L. M., Painter, R., Vessey, M. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074516/
https://www.ncbi.nlm.nih.gov/pubmed/8630295
_version_ 1782137983520997376
author Zondervan, K. T.
Carpenter, L. M.
Painter, R.
Vessey, M. P.
author_facet Zondervan, K. T.
Carpenter, L. M.
Painter, R.
Vessey, M. P.
author_sort Zondervan, K. T.
collection PubMed
description In 1983, we reported results from the Oxford Family Planning Association contraceptive study regarding the association between oral contraceptives (OCs) and cervical neoplasia, after a 10 year follow-up of a cohort of 17,000 women. Further findings from this study are reported here after an additional 12 years of follow-up. A nested case--control design was used in which cases were all women diagnosed under 45 years of age with invasive carcinoma (n = 33), carcinoma in situ (n = 121) or dysplasia (n = 159). Controls were randomly selected from among cohort members and matched to cases on exact year of birth and clinic attended at recruitment to study. Conditional logistic regression analysis was used to determine odds ratios (ORs) and 95% confidence intervals (CIs) associated with various aspects of OC use relative to never users adjusted for social class, smoking, age at first birth and ever use of diaphragm or condom. Ever users of OCs had a slightly elevated OR for all types of cervical neoplasia combined (OR = 1.40, 95% CI 1.00-1.96). Odds ratios were highest for invasive carcinoma (OR = 4.44, 95% CI 1.04-31.6), intermediate for carcinoma in situ (OR = 1.73, 95% CI 1.00-3.00) and lowest for dysplasia (OR = 1.07, 95% CI 0.69-1.66). The elevated risk associated with OC use appeared to be largely confined to current or recent (last use in the past 2 years) long-term users of OCs. Among current or recent users, ORs for all types of cervical neoplasia combined were 3.34 (95% CI 1.96-5.67) for 49-72 months of use, 1.69 (95% CI 0.97-2.95) for 73-96 months and 2.04 (95% CI 1.34-3.11) for 97 or more months. These results suggest a possible effect of OC use on later stages of cervical carcinogenesis, although residual confounding due to sexual factors or human papillomavirus (HPV) infection cannot be ruled out.
format Text
id pubmed-2074516
institution National Center for Biotechnology Information
language English
publishDate 1996
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20745162009-09-10 Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study. Zondervan, K. T. Carpenter, L. M. Painter, R. Vessey, M. P. Br J Cancer Research Article In 1983, we reported results from the Oxford Family Planning Association contraceptive study regarding the association between oral contraceptives (OCs) and cervical neoplasia, after a 10 year follow-up of a cohort of 17,000 women. Further findings from this study are reported here after an additional 12 years of follow-up. A nested case--control design was used in which cases were all women diagnosed under 45 years of age with invasive carcinoma (n = 33), carcinoma in situ (n = 121) or dysplasia (n = 159). Controls were randomly selected from among cohort members and matched to cases on exact year of birth and clinic attended at recruitment to study. Conditional logistic regression analysis was used to determine odds ratios (ORs) and 95% confidence intervals (CIs) associated with various aspects of OC use relative to never users adjusted for social class, smoking, age at first birth and ever use of diaphragm or condom. Ever users of OCs had a slightly elevated OR for all types of cervical neoplasia combined (OR = 1.40, 95% CI 1.00-1.96). Odds ratios were highest for invasive carcinoma (OR = 4.44, 95% CI 1.04-31.6), intermediate for carcinoma in situ (OR = 1.73, 95% CI 1.00-3.00) and lowest for dysplasia (OR = 1.07, 95% CI 0.69-1.66). The elevated risk associated with OC use appeared to be largely confined to current or recent (last use in the past 2 years) long-term users of OCs. Among current or recent users, ORs for all types of cervical neoplasia combined were 3.34 (95% CI 1.96-5.67) for 49-72 months of use, 1.69 (95% CI 0.97-2.95) for 73-96 months and 2.04 (95% CI 1.34-3.11) for 97 or more months. These results suggest a possible effect of OC use on later stages of cervical carcinogenesis, although residual confounding due to sexual factors or human papillomavirus (HPV) infection cannot be ruled out. Nature Publishing Group 1996-05 /pmc/articles/PMC2074516/ /pubmed/8630295 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Zondervan, K. T.
Carpenter, L. M.
Painter, R.
Vessey, M. P.
Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title_full Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title_fullStr Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title_full_unstemmed Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title_short Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.
title_sort oral contraceptives and cervical cancer--further findings from the oxford family planning association contraceptive study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074516/
https://www.ncbi.nlm.nih.gov/pubmed/8630295
work_keys_str_mv AT zondervankt oralcontraceptivesandcervicalcancerfurtherfindingsfromtheoxfordfamilyplanningassociationcontraceptivestudy
AT carpenterlm oralcontraceptivesandcervicalcancerfurtherfindingsfromtheoxfordfamilyplanningassociationcontraceptivestudy
AT painterr oralcontraceptivesandcervicalcancerfurtherfindingsfromtheoxfordfamilyplanningassociationcontraceptivestudy
AT vesseymp oralcontraceptivesandcervicalcancerfurtherfindingsfromtheoxfordfamilyplanningassociationcontraceptivestudy