Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.

The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14...

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Autores principales: Shi, Y. F., Xie, X., Zhao, C. L., Ye, D. F., Lu, S. M., Hor, J. J., Pao, C. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074525/
https://www.ncbi.nlm.nih.gov/pubmed/8630281
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author Shi, Y. F.
Xie, X.
Zhao, C. L.
Ye, D. F.
Lu, S. M.
Hor, J. J.
Pao, C. C.
author_facet Shi, Y. F.
Xie, X.
Zhao, C. L.
Ye, D. F.
Lu, S. M.
Hor, J. J.
Pao, C. C.
author_sort Shi, Y. F.
collection PubMed
description The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14 hydatidiform moles, six invasive moles, eight choriocarcinomas and ten normal early placental tissues. No mutation in exons 5-8 was detected in any of these 38 tissue specimens. These results suggest that a mutation in p53 tumour suppressor either does not exist or is a very rare event in gestational trophoblastic tumours. The gestational trophoblastic tumours probably involve a tumour-suppressor gene other than p53 gene or may follow a completely different pathway to their malignant phenotype. IMAGES:
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spelling pubmed-20745252009-09-10 Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours. Shi, Y. F. Xie, X. Zhao, C. L. Ye, D. F. Lu, S. M. Hor, J. J. Pao, C. C. Br J Cancer Research Article The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14 hydatidiform moles, six invasive moles, eight choriocarcinomas and ten normal early placental tissues. No mutation in exons 5-8 was detected in any of these 38 tissue specimens. These results suggest that a mutation in p53 tumour suppressor either does not exist or is a very rare event in gestational trophoblastic tumours. The gestational trophoblastic tumours probably involve a tumour-suppressor gene other than p53 gene or may follow a completely different pathway to their malignant phenotype. IMAGES: Nature Publishing Group 1996-05 /pmc/articles/PMC2074525/ /pubmed/8630281 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shi, Y. F.
Xie, X.
Zhao, C. L.
Ye, D. F.
Lu, S. M.
Hor, J. J.
Pao, C. C.
Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_full Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_fullStr Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_full_unstemmed Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_short Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_sort lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074525/
https://www.ncbi.nlm.nih.gov/pubmed/8630281
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