Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.

Urinary gonadotropin peptide (UGP) levels were determined in urine samples from 450 Egyptian subjects to determine its relative level of expression in benign and malignant urological disease, and normal individuals. The mean UGP level in patients with bladder cancer was 44-fold higher than in patien...

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Autores principales: el-Ahmady, O., Halim, A. B., Mansour, O., Salman, T., el-Din, A. G., Walker, R. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074546/
https://www.ncbi.nlm.nih.gov/pubmed/8664117
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author el-Ahmady, O.
Halim, A. B.
Mansour, O.
Salman, T.
el-Din, A. G.
Walker, R. P.
author_facet el-Ahmady, O.
Halim, A. B.
Mansour, O.
Salman, T.
el-Din, A. G.
Walker, R. P.
author_sort el-Ahmady, O.
collection PubMed
description Urinary gonadotropin peptide (UGP) levels were determined in urine samples from 450 Egyptian subjects to determine its relative level of expression in benign and malignant urological disease, and normal individuals. The mean UGP level in patients with bladder cancer was 44-fold higher than in patients with benign disease, and 81-fold higher than in normal individuals. At specificities of 95% and 100%, overall sensitivities of 73% and 60%, respectively, were observed for the detection of malignant disease. Mean UGP levels in patients with bladder cancer were significantly correlated with the stage and grade of malignant disease but did not vary significantly when stratified according to histological type of disease, nodal involvement or bilharzial association. UGP could be a potentially useful marker for the differentiation of benign from malignant urological disease.
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spelling pubmed-20745462009-09-10 Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease. el-Ahmady, O. Halim, A. B. Mansour, O. Salman, T. el-Din, A. G. Walker, R. P. Br J Cancer Research Article Urinary gonadotropin peptide (UGP) levels were determined in urine samples from 450 Egyptian subjects to determine its relative level of expression in benign and malignant urological disease, and normal individuals. The mean UGP level in patients with bladder cancer was 44-fold higher than in patients with benign disease, and 81-fold higher than in normal individuals. At specificities of 95% and 100%, overall sensitivities of 73% and 60%, respectively, were observed for the detection of malignant disease. Mean UGP levels in patients with bladder cancer were significantly correlated with the stage and grade of malignant disease but did not vary significantly when stratified according to histological type of disease, nodal involvement or bilharzial association. UGP could be a potentially useful marker for the differentiation of benign from malignant urological disease. Nature Publishing Group 1996-06 /pmc/articles/PMC2074546/ /pubmed/8664117 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
el-Ahmady, O.
Halim, A. B.
Mansour, O.
Salman, T.
el-Din, A. G.
Walker, R. P.
Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title_full Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title_fullStr Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title_full_unstemmed Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title_short Urinary gonadotropin peptide (UGP) in Egyptian patients with benign and advanced malignant urological disease.
title_sort urinary gonadotropin peptide (ugp) in egyptian patients with benign and advanced malignant urological disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074546/
https://www.ncbi.nlm.nih.gov/pubmed/8664117
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