Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.

The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed...

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Autores principales: Lösch, A., Kohlberger, P., Gitsch, G., Kaider, A., Breitenecker, G., Kainz, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074555/
https://www.ncbi.nlm.nih.gov/pubmed/8664123
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author Lösch, A.
Kohlberger, P.
Gitsch, G.
Kaider, A.
Breitenecker, G.
Kainz, C.
author_facet Lösch, A.
Kohlberger, P.
Gitsch, G.
Kaider, A.
Breitenecker, G.
Kainz, C.
author_sort Lösch, A.
collection PubMed
description The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma. IMAGES:
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spelling pubmed-20745552009-09-10 Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer. Lösch, A. Kohlberger, P. Gitsch, G. Kaider, A. Breitenecker, G. Kainz, C. Br J Cancer Research Article The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma. IMAGES: Nature Publishing Group 1996-06 /pmc/articles/PMC2074555/ /pubmed/8664123 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lösch, A.
Kohlberger, P.
Gitsch, G.
Kaider, A.
Breitenecker, G.
Kainz, C.
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_full Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_fullStr Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_full_unstemmed Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_short Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_sort lysosomal protease cathepsin d is a prognostic marker in endometrial cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074555/
https://www.ncbi.nlm.nih.gov/pubmed/8664123
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