Cargando…
Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population.
Data on myelodysplastic syndromes (MDS) are seldom collected by cancer registries and unbiased findings from population-based studies remain rare. We report detailed information on MDS in a well-defined French population in the period 1980-1990. The crude incidence rate was 3.2 per 100000 per year a...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1996
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074591/ https://www.ncbi.nlm.nih.gov/pubmed/8688338 |
_version_ | 1782137999565258752 |
---|---|
author | Maynadié, M. Verret, C. Moskovtchenko, P. Mugneret, F. Petrella, T. Caillot, D. Carli, P. M. |
author_facet | Maynadié, M. Verret, C. Moskovtchenko, P. Mugneret, F. Petrella, T. Caillot, D. Carli, P. M. |
author_sort | Maynadié, M. |
collection | PubMed |
description | Data on myelodysplastic syndromes (MDS) are seldom collected by cancer registries and unbiased findings from population-based studies remain rare. We report detailed information on MDS in a well-defined French population in the period 1980-1990. The crude incidence rate was 3.2 per 100000 per year and no significant change in incidence was noted in the study period. The sex ratio was 1.9 and the male predominance was present in all age groups. We observed a rise in incidence after 60 years of age but no significant change in incidence of MDS as a whole was observed over the period studied. Refractory anaemia with excess of blasts (RAEB) was the most frequent subtype. Overall 5 year transformation rate of MDS was 31% (+/- 4%) but it was 100% in RAEB in transformation. The observed 5 year survival rate was 23% +/- 3% and the corresponding corrected rate was 33%. The prognosis of RAEB in transformation was worse than the prognosis of other subtypes (P < 0.01). Discrepancies with epidemiological data from other European countries are discussed. |
format | Text |
id | pubmed-2074591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20745912009-09-10 Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. Maynadié, M. Verret, C. Moskovtchenko, P. Mugneret, F. Petrella, T. Caillot, D. Carli, P. M. Br J Cancer Research Article Data on myelodysplastic syndromes (MDS) are seldom collected by cancer registries and unbiased findings from population-based studies remain rare. We report detailed information on MDS in a well-defined French population in the period 1980-1990. The crude incidence rate was 3.2 per 100000 per year and no significant change in incidence was noted in the study period. The sex ratio was 1.9 and the male predominance was present in all age groups. We observed a rise in incidence after 60 years of age but no significant change in incidence of MDS as a whole was observed over the period studied. Refractory anaemia with excess of blasts (RAEB) was the most frequent subtype. Overall 5 year transformation rate of MDS was 31% (+/- 4%) but it was 100% in RAEB in transformation. The observed 5 year survival rate was 23% +/- 3% and the corresponding corrected rate was 33%. The prognosis of RAEB in transformation was worse than the prognosis of other subtypes (P < 0.01). Discrepancies with epidemiological data from other European countries are discussed. Nature Publishing Group 1996-07 /pmc/articles/PMC2074591/ /pubmed/8688338 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Maynadié, M. Verret, C. Moskovtchenko, P. Mugneret, F. Petrella, T. Caillot, D. Carli, P. M. Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title | Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title_full | Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title_fullStr | Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title_full_unstemmed | Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title_short | Epidemiological characteristics of myelodysplastic syndrome in a well-defined French population. |
title_sort | epidemiological characteristics of myelodysplastic syndrome in a well-defined french population. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074591/ https://www.ncbi.nlm.nih.gov/pubmed/8688338 |
work_keys_str_mv | AT maynadiem epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT verretc epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT moskovtchenkop epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT mugneretf epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT petrellat epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT caillotd epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation AT carlipm epidemiologicalcharacteristicsofmyelodysplasticsyndromeinawelldefinedfrenchpopulation |