An analysis of surveillance for stage I combined teratoma--seminoma of the testis.

We analysed 973 patients with stage I testicular tumours presenting between 1983 and 1994. The median ages at presentation for non-seminomatous germ cell tumour (teratoma) were 27 years, seminoma 36 years and combined tumour 33 years. These differences were statistically significant (Mann-Whitney P...

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Autores principales: Thomas, R., Dearnaley, D., Nicholls, J., Norman, A., Sampson, S., Horwich, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074607/
https://www.ncbi.nlm.nih.gov/pubmed/8679458
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author Thomas, R.
Dearnaley, D.
Nicholls, J.
Norman, A.
Sampson, S.
Horwich, A.
author_facet Thomas, R.
Dearnaley, D.
Nicholls, J.
Norman, A.
Sampson, S.
Horwich, A.
author_sort Thomas, R.
collection PubMed
description We analysed 973 patients with stage I testicular tumours presenting between 1983 and 1994. The median ages at presentation for non-seminomatous germ cell tumour (teratoma) were 27 years, seminoma 36 years and combined tumour 33 years. These differences were statistically significant (Mann-Whitney P < 0.05), suggesting that combined tumours may have a separate natural history. We, therefore, analysed all stage I patients managed with surveillance (530 in total) post orchidectomy. The actuarial 5 year relapse-free survival and anatomical patterns of relapse were identical for non-seminomatous germ cell tumour (NSGCT) and combined tumour and both were statistically distinct from seminoma (P = 0.01, log-rank test, chi-square test P = 0.001). The association of seminoma within a histologically confirmed NSGCT has no influence on the clinical outcome. IMAGES:
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spelling pubmed-20746072009-09-10 An analysis of surveillance for stage I combined teratoma--seminoma of the testis. Thomas, R. Dearnaley, D. Nicholls, J. Norman, A. Sampson, S. Horwich, A. Br J Cancer Research Article We analysed 973 patients with stage I testicular tumours presenting between 1983 and 1994. The median ages at presentation for non-seminomatous germ cell tumour (teratoma) were 27 years, seminoma 36 years and combined tumour 33 years. These differences were statistically significant (Mann-Whitney P < 0.05), suggesting that combined tumours may have a separate natural history. We, therefore, analysed all stage I patients managed with surveillance (530 in total) post orchidectomy. The actuarial 5 year relapse-free survival and anatomical patterns of relapse were identical for non-seminomatous germ cell tumour (NSGCT) and combined tumour and both were statistically distinct from seminoma (P = 0.01, log-rank test, chi-square test P = 0.001). The association of seminoma within a histologically confirmed NSGCT has no influence on the clinical outcome. IMAGES: Nature Publishing Group 1996-07 /pmc/articles/PMC2074607/ /pubmed/8679458 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thomas, R.
Dearnaley, D.
Nicholls, J.
Norman, A.
Sampson, S.
Horwich, A.
An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title_full An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title_fullStr An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title_full_unstemmed An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title_short An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
title_sort analysis of surveillance for stage i combined teratoma--seminoma of the testis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074607/
https://www.ncbi.nlm.nih.gov/pubmed/8679458
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