No evidence of microsatellite instability in bone tumours.

Microsatellite instability has recently been reported in sporadic and familial colorectal tumours and can be due to defects in DNA mismatch repair genes. Such instability has subsequently been detected in several other types of sporadic tumours. We studied 29 specimens of bone tumours with different...

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Autores principales: Tarkkanen, M., Aaltonen, L. A., Böhling, T., Kivioja, A., Karaharju, E., Elomaa, I., Knuutila, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074653/
https://www.ncbi.nlm.nih.gov/pubmed/8695363
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author Tarkkanen, M.
Aaltonen, L. A.
Böhling, T.
Kivioja, A.
Karaharju, E.
Elomaa, I.
Knuutila, S.
author_facet Tarkkanen, M.
Aaltonen, L. A.
Böhling, T.
Kivioja, A.
Karaharju, E.
Elomaa, I.
Knuutila, S.
author_sort Tarkkanen, M.
collection PubMed
description Microsatellite instability has recently been reported in sporadic and familial colorectal tumours and can be due to defects in DNA mismatch repair genes. Such instability has subsequently been detected in several other types of sporadic tumours. We studied 29 specimens of bone tumours with different histopathological diagnoses and found no evidence of microsatellite instability. Our results suggest that mismatch repair defects are unlikely to play a significant part in the tumorigenesis of bone neoplasms. Loss of heterozygosity with at least one marker was detected in 11, i.e. in 38% of the tumour samples, most frequently with markers D2S136 at 2p (eight of 28 informative specimens, 29%) and D11S904 at 11p (four of 21 informative specimens, 19%). IMAGES:
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spelling pubmed-20746532009-09-10 No evidence of microsatellite instability in bone tumours. Tarkkanen, M. Aaltonen, L. A. Böhling, T. Kivioja, A. Karaharju, E. Elomaa, I. Knuutila, S. Br J Cancer Research Article Microsatellite instability has recently been reported in sporadic and familial colorectal tumours and can be due to defects in DNA mismatch repair genes. Such instability has subsequently been detected in several other types of sporadic tumours. We studied 29 specimens of bone tumours with different histopathological diagnoses and found no evidence of microsatellite instability. Our results suggest that mismatch repair defects are unlikely to play a significant part in the tumorigenesis of bone neoplasms. Loss of heterozygosity with at least one marker was detected in 11, i.e. in 38% of the tumour samples, most frequently with markers D2S136 at 2p (eight of 28 informative specimens, 29%) and D11S904 at 11p (four of 21 informative specimens, 19%). IMAGES: Nature Publishing Group 1996-08 /pmc/articles/PMC2074653/ /pubmed/8695363 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tarkkanen, M.
Aaltonen, L. A.
Böhling, T.
Kivioja, A.
Karaharju, E.
Elomaa, I.
Knuutila, S.
No evidence of microsatellite instability in bone tumours.
title No evidence of microsatellite instability in bone tumours.
title_full No evidence of microsatellite instability in bone tumours.
title_fullStr No evidence of microsatellite instability in bone tumours.
title_full_unstemmed No evidence of microsatellite instability in bone tumours.
title_short No evidence of microsatellite instability in bone tumours.
title_sort no evidence of microsatellite instability in bone tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074653/
https://www.ncbi.nlm.nih.gov/pubmed/8695363
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