Cargando…
A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor.
ZD1694 ('Tomudex'), a novel, direct and specific thymidylate synthase (TS) inhibitor, was developed in a collaborative research programme between Zeneca Pharmaceuticals and the Institute of Cancer Research (UK) and entered clinical trials in 1991; phase II studies began in 1992, using 3.0...
Autores principales: | Smith, I., Jones, A., Spielmann, M., Namer, M., Green, M. D., Bonneterre, J., Wander, H. E., Hatschek, T., Wilking, N., Zalcberg, J., Spiers, J., Seymour, L. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1996
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074654/ https://www.ncbi.nlm.nih.gov/pubmed/8695369 |
Ejemplares similares
-
Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models.
por: Aherne, G. W., et al.
Publicado: (1998) -
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
por: Jackman, A. L., et al.
Publicado: (1995) -
Effects of impaired renal function on the pharmacokinetics of raltitrexed (Tomudex ZD1694).
por: Judson, I., et al.
Publicado: (1998) -
Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.
por: Freemantle, S. J., et al.
Publicado: (1995) -
New developments in cancer treatment with the novel thymidylate synthase inhibitor raltitrexed ('Tomudex').
por: Blackledge, G.
Publicado: (1998)