Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.

The purpose of the present study was to explore the therapeutic potential of serial administration of shedding-inducing endotoxin in a mouse tumour bladder model. The studies were conducted with two variants derived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than...

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Autores principales: Nativ, O., Medalia, O., Mor, Y., Shajrawi, I., Sabo, E., Aronson, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074659/
https://www.ncbi.nlm.nih.gov/pubmed/8761377
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author Nativ, O.
Medalia, O.
Mor, Y.
Shajrawi, I.
Sabo, E.
Aronson, M.
author_facet Nativ, O.
Medalia, O.
Mor, Y.
Shajrawi, I.
Sabo, E.
Aronson, M.
author_sort Nativ, O.
collection PubMed
description The purpose of the present study was to explore the therapeutic potential of serial administration of shedding-inducing endotoxin in a mouse tumour bladder model. The studies were conducted with two variants derived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than the former. It was found that T5 tumours responded to intravesical lipopolysaccharides (LPS) instillation by a considerable reduction in their pace of growth (P < 0.0001) when treatment was initiated 3 days after tumour implantation, but not when started after 7 days. The T50 variant did not respond to LPS when treated 3 days after implantation, but a considerable reduction in rate of growth occurred when treatment was started after 1-2 days. Shedding induced by intravesically instilled LPS was found to retard considerably the progression rate of experimental bladder tumour.
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spelling pubmed-20746592009-09-10 Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding. Nativ, O. Medalia, O. Mor, Y. Shajrawi, I. Sabo, E. Aronson, M. Br J Cancer Research Article The purpose of the present study was to explore the therapeutic potential of serial administration of shedding-inducing endotoxin in a mouse tumour bladder model. The studies were conducted with two variants derived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than the former. It was found that T5 tumours responded to intravesical lipopolysaccharides (LPS) instillation by a considerable reduction in their pace of growth (P < 0.0001) when treatment was initiated 3 days after tumour implantation, but not when started after 7 days. The T50 variant did not respond to LPS when treated 3 days after implantation, but a considerable reduction in rate of growth occurred when treatment was started after 1-2 days. Shedding induced by intravesically instilled LPS was found to retard considerably the progression rate of experimental bladder tumour. Nature Publishing Group 1996-08 /pmc/articles/PMC2074659/ /pubmed/8761377 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nativ, O.
Medalia, O.
Mor, Y.
Shajrawi, I.
Sabo, E.
Aronson, M.
Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title_full Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title_fullStr Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title_full_unstemmed Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title_short Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding.
title_sort treatment of experimental mouse bladder tumour by lps-induced epithelial cell shedding.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074659/
https://www.ncbi.nlm.nih.gov/pubmed/8761377
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