Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.

We have developed chimeric Fab fragments of MAb A7 (chA7Fab) and have reported on their potential usefulness as a carrier of neocarzinostatin (NCS). However, a large amount of chA7Fab accumulates in the kidneys which might cause renal failure. This was one of the major side-effects of the chA7Fab-NC...

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Detalles Bibliográficos
Autores principales: Otsuji, E., Yamaguchi, T., Matsumura, H., Yamamoto, K., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Kitamura, K., Takahashi, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074675/
https://www.ncbi.nlm.nih.gov/pubmed/8761376

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