Characterisation of seven human ovarian tumour cell lines.

Characteristics of a panel of seven human ovarian tumour cell lines are presented. Positive staining with HMFG2 and ultrastructural identification of desmosomes confirmed the epithelial nature of the cell lines. The lines showed wide variations in ploidy, doubling times and clonogenicity in soft aga...

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Autores principales: Wilson, A. P., Dent, M., Pejovic, T., Hubbold, L., Radford, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074705/
https://www.ncbi.nlm.nih.gov/pubmed/8795574
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author Wilson, A. P.
Dent, M.
Pejovic, T.
Hubbold, L.
Radford, H.
author_facet Wilson, A. P.
Dent, M.
Pejovic, T.
Hubbold, L.
Radford, H.
author_sort Wilson, A. P.
collection PubMed
description Characteristics of a panel of seven human ovarian tumour cell lines are presented. Positive staining with HMFG2 and ultrastructural identification of desmosomes confirmed the epithelial nature of the cell lines. The lines showed wide variations in ploidy, doubling times and clonogenicity in soft agar. Both vimentin and keratin were equally expressed in five lines, one line showed strong preferential expression of keratin and one line showed preferential expression of vimentin. Karyotypic changes associated with ovarian cancer were identified in all the lines. Four of the seven cell lines showed loss of chromosome material distal to 11p13-15. These cell lines offer considerable potential for research into the biology and genetics of ovarian cancer. IMAGES:
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spelling pubmed-20747052009-09-10 Characterisation of seven human ovarian tumour cell lines. Wilson, A. P. Dent, M. Pejovic, T. Hubbold, L. Radford, H. Br J Cancer Research Article Characteristics of a panel of seven human ovarian tumour cell lines are presented. Positive staining with HMFG2 and ultrastructural identification of desmosomes confirmed the epithelial nature of the cell lines. The lines showed wide variations in ploidy, doubling times and clonogenicity in soft agar. Both vimentin and keratin were equally expressed in five lines, one line showed strong preferential expression of keratin and one line showed preferential expression of vimentin. Karyotypic changes associated with ovarian cancer were identified in all the lines. Four of the seven cell lines showed loss of chromosome material distal to 11p13-15. These cell lines offer considerable potential for research into the biology and genetics of ovarian cancer. IMAGES: Nature Publishing Group 1996-09 /pmc/articles/PMC2074705/ /pubmed/8795574 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wilson, A. P.
Dent, M.
Pejovic, T.
Hubbold, L.
Radford, H.
Characterisation of seven human ovarian tumour cell lines.
title Characterisation of seven human ovarian tumour cell lines.
title_full Characterisation of seven human ovarian tumour cell lines.
title_fullStr Characterisation of seven human ovarian tumour cell lines.
title_full_unstemmed Characterisation of seven human ovarian tumour cell lines.
title_short Characterisation of seven human ovarian tumour cell lines.
title_sort characterisation of seven human ovarian tumour cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074705/
https://www.ncbi.nlm.nih.gov/pubmed/8795574
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