Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.

Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent ve...

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Detalles Bibliográficos
Autores principales: Duffy, P. M., Hayes, M. C., Cooper, A., Smart, C. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074719/
https://www.ncbi.nlm.nih.gov/pubmed/8826856
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author Duffy, P. M.
Hayes, M. C.
Cooper, A.
Smart, C. J.
author_facet Duffy, P. M.
Hayes, M. C.
Cooper, A.
Smart, C. J.
author_sort Duffy, P. M.
collection PubMed
description Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent verapamil. Our results contrast with studies on conventional anthracyclines and suggest that nuclear accumulation may not be a prerequisite for anthracycline cytotoxicity. IMAGES:
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spelling pubmed-20747192009-09-10 Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines. Duffy, P. M. Hayes, M. C. Cooper, A. Smart, C. J. Br J Cancer Research Article Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent verapamil. Our results contrast with studies on conventional anthracyclines and suggest that nuclear accumulation may not be a prerequisite for anthracycline cytotoxicity. IMAGES: Nature Publishing Group 1996-09 /pmc/articles/PMC2074719/ /pubmed/8826856 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Duffy, P. M.
Hayes, M. C.
Cooper, A.
Smart, C. J.
Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title_full Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title_fullStr Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title_full_unstemmed Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title_short Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
title_sort confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074719/
https://www.ncbi.nlm.nih.gov/pubmed/8826856
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AT coopera confocalmicroscopyofidarubicinlocalisationinsensitiveandmultidrugresistantbladdercancercelllines
AT smartcj confocalmicroscopyofidarubicinlocalisationinsensitiveandmultidrugresistantbladdercancercelllines

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