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Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.

Cyclin E is a G1 cyclin which has been proposed to be one of the key regulators of the important G1/S transition, and could consequently be a potential deregulated molecule in tumours. Recently, it has been observed that cyclin E is overexpressed in a variety of malignancies including breast cancer...

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Autores principales: Nielsen, N. H., Arnerlöv, C., Emdin, S. O., Landberg, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074748/
https://www.ncbi.nlm.nih.gov/pubmed/8826852
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author Nielsen, N. H.
Arnerlöv, C.
Emdin, S. O.
Landberg, G.
author_facet Nielsen, N. H.
Arnerlöv, C.
Emdin, S. O.
Landberg, G.
author_sort Nielsen, N. H.
collection PubMed
description Cyclin E is a G1 cyclin which has been proposed to be one of the key regulators of the important G1/S transition, and could consequently be a potential deregulated molecule in tumours. Recently, it has been observed that cyclin E is overexpressed in a variety of malignancies including breast cancer and that several isoforms of the protein exists. In this study we have characterised the cyclin E expression in 114 tumour specimens from patients with primary breast cancer using Western blotting. Various expression of cyclin E was observed among tumours and a group of 27 patients out of 100 patients with stage I-III disease, identified as having tumours with high cyclin E levels, had a significantly increased risk of death and relapse from breast cancer (P = 0.0002 and P = 0.015 respectively). Even in the subgroup of axillary node-negative patients the cyclin E level was of prognostic importance. There was also a strong association between cyclin E expression and oestrogen receptor status (P < 0.00001), and tumours with high cyclin E expression were in general oestrogen receptor negative, suggesting a potential role for cyclin E in mechanisms responsible for oestrogen-independent tumour growth. IMAGES:
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spelling pubmed-20747482009-09-10 Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status. Nielsen, N. H. Arnerlöv, C. Emdin, S. O. Landberg, G. Br J Cancer Research Article Cyclin E is a G1 cyclin which has been proposed to be one of the key regulators of the important G1/S transition, and could consequently be a potential deregulated molecule in tumours. Recently, it has been observed that cyclin E is overexpressed in a variety of malignancies including breast cancer and that several isoforms of the protein exists. In this study we have characterised the cyclin E expression in 114 tumour specimens from patients with primary breast cancer using Western blotting. Various expression of cyclin E was observed among tumours and a group of 27 patients out of 100 patients with stage I-III disease, identified as having tumours with high cyclin E levels, had a significantly increased risk of death and relapse from breast cancer (P = 0.0002 and P = 0.015 respectively). Even in the subgroup of axillary node-negative patients the cyclin E level was of prognostic importance. There was also a strong association between cyclin E expression and oestrogen receptor status (P < 0.00001), and tumours with high cyclin E expression were in general oestrogen receptor negative, suggesting a potential role for cyclin E in mechanisms responsible for oestrogen-independent tumour growth. IMAGES: Nature Publishing Group 1996-09 /pmc/articles/PMC2074748/ /pubmed/8826852 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nielsen, N. H.
Arnerlöv, C.
Emdin, S. O.
Landberg, G.
Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title_full Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title_fullStr Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title_full_unstemmed Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title_short Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
title_sort cyclin e overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074748/
https://www.ncbi.nlm.nih.gov/pubmed/8826852
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