Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.

Twenty-four cases of histologically defined follicle centre cell (FCC) lymphoma have been examined for allele imbalance at 19 microsatellite loci spanning the length of chromosome 6, including six markers within the major histocompatibility complex (MHC), using fluorescent polymerase chain reaction...

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Autores principales: Randerson, J., Cawkwell, L., Jack, A., Lewis, F., Johnson, P., Evans, P., Barrans, S., Morgan, G. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074751/
https://www.ncbi.nlm.nih.gov/pubmed/8826862
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author Randerson, J.
Cawkwell, L.
Jack, A.
Lewis, F.
Johnson, P.
Evans, P.
Barrans, S.
Morgan, G. J.
author_facet Randerson, J.
Cawkwell, L.
Jack, A.
Lewis, F.
Johnson, P.
Evans, P.
Barrans, S.
Morgan, G. J.
author_sort Randerson, J.
collection PubMed
description Twenty-four cases of histologically defined follicle centre cell (FCC) lymphoma have been examined for allele imbalance at 19 microsatellite loci spanning the length of chromosome 6, including six markers within the major histocompatibility complex (MHC), using fluorescent polymerase chain reaction (PCR) to amplify microsatellites. Nineteen cases were observed in which imbalance of one or more markers on chromosome 6 had occurred (79%). The frequency of allele imbalance was significantly higher on 6p than 6q, and two regions of deletions, 6p24-25 and 6p21.3-23, were identified in which the loci showed a significantly high allele imbalance frequency.
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spelling pubmed-20747512009-09-10 Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma. Randerson, J. Cawkwell, L. Jack, A. Lewis, F. Johnson, P. Evans, P. Barrans, S. Morgan, G. J. Br J Cancer Research Article Twenty-four cases of histologically defined follicle centre cell (FCC) lymphoma have been examined for allele imbalance at 19 microsatellite loci spanning the length of chromosome 6, including six markers within the major histocompatibility complex (MHC), using fluorescent polymerase chain reaction (PCR) to amplify microsatellites. Nineteen cases were observed in which imbalance of one or more markers on chromosome 6 had occurred (79%). The frequency of allele imbalance was significantly higher on 6p than 6q, and two regions of deletions, 6p24-25 and 6p21.3-23, were identified in which the loci showed a significantly high allele imbalance frequency. Nature Publishing Group 1996-09 /pmc/articles/PMC2074751/ /pubmed/8826862 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Randerson, J.
Cawkwell, L.
Jack, A.
Lewis, F.
Johnson, P.
Evans, P.
Barrans, S.
Morgan, G. J.
Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title_full Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title_fullStr Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title_full_unstemmed Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title_short Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
title_sort fluorescent polymerase chain reaction of a panel of ca repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074751/
https://www.ncbi.nlm.nih.gov/pubmed/8826862
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