Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.

Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies against AMF-R (gp78) were used to stain 221 primary gastric cancer specimens, and level of exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Hirono, Y., Fushida, S., Yonemura, Y., Yamamoto, H., Watanabe, H., Raz, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074811/
https://www.ncbi.nlm.nih.gov/pubmed/8980404
_version_ 1782138047858475008
author Hirono, Y.
Fushida, S.
Yonemura, Y.
Yamamoto, H.
Watanabe, H.
Raz, A.
author_facet Hirono, Y.
Fushida, S.
Yonemura, Y.
Yamamoto, H.
Watanabe, H.
Raz, A.
author_sort Hirono, Y.
collection PubMed
description Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies against AMF-R (gp78) were used to stain 221 primary gastric cancer specimens, and level of expression was examined in relation to pathological stage and prognostic values. In 125 out of 221 (56.6%) patients, gp78 was detected. Expression of gp78 was associated with macroscopic type, lymphatic and venous invasions, and lymph node and peritoneal metastasis. The level of gp78 expression in the cancer specimens was associated with histopathological stage and grade of tumour penetration. Positive gp78 expression was significantly associated with poor prognosis (P < 0.001). This significant relationship remained among patients in stage II and III. The results suggest that gp78 expression could be used as a prognostic marker in gastric cancer patients. IMAGES:
format Text
id pubmed-2074811
institution National Center for Biotechnology Information
language English
publishDate 1996
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20748112009-09-10 Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer. Hirono, Y. Fushida, S. Yonemura, Y. Yamamoto, H. Watanabe, H. Raz, A. Br J Cancer Research Article Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies against AMF-R (gp78) were used to stain 221 primary gastric cancer specimens, and level of expression was examined in relation to pathological stage and prognostic values. In 125 out of 221 (56.6%) patients, gp78 was detected. Expression of gp78 was associated with macroscopic type, lymphatic and venous invasions, and lymph node and peritoneal metastasis. The level of gp78 expression in the cancer specimens was associated with histopathological stage and grade of tumour penetration. Positive gp78 expression was significantly associated with poor prognosis (P < 0.001). This significant relationship remained among patients in stage II and III. The results suggest that gp78 expression could be used as a prognostic marker in gastric cancer patients. IMAGES: Nature Publishing Group 1996-12 /pmc/articles/PMC2074811/ /pubmed/8980404 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hirono, Y.
Fushida, S.
Yonemura, Y.
Yamamoto, H.
Watanabe, H.
Raz, A.
Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title_full Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title_fullStr Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title_full_unstemmed Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title_short Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
title_sort expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074811/
https://www.ncbi.nlm.nih.gov/pubmed/8980404
work_keys_str_mv AT hironoy expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer
AT fushidas expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer
AT yonemuray expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer
AT yamamotoh expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer
AT watanabeh expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer
AT raza expressionofautocrinemotilityfactorreceptorcorrelateswithdiseaseprogressioninhumangastriccancer

Ejemplares similares