CAM 17.1--a new diagnostic marker in pancreatic cancer.

CAM 17.1-Ab is a recently described monoclonal antibody that detects a mucus glycoprotein with high specificity for intestinal mucus, particularly in the colon, small intestine, biliary tract and pancreas. We investigated the expression and release of CAM 17.1 in pancreatic carcinoma cell lines and...

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Autores principales: Gansauge, F., Gansauge, S., Parker, N., Beger, M. I., Poch, B., Link, K. H., Safi, F., Beger, H. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074816/
https://www.ncbi.nlm.nih.gov/pubmed/8980403
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author Gansauge, F.
Gansauge, S.
Parker, N.
Beger, M. I.
Poch, B.
Link, K. H.
Safi, F.
Beger, H. G.
author_facet Gansauge, F.
Gansauge, S.
Parker, N.
Beger, M. I.
Poch, B.
Link, K. H.
Safi, F.
Beger, H. G.
author_sort Gansauge, F.
collection PubMed
description CAM 17.1-Ab is a recently described monoclonal antibody that detects a mucus glycoprotein with high specificity for intestinal mucus, particularly in the colon, small intestine, biliary tract and pancreas. We investigated the expression and release of CAM 17.1 in pancreatic carcinoma cell lines and tissue specimens of normal pancreas, chronic pancreatitis and pancreatic cancer. CAM 17.1 was weakly expressed on normal ductal cells and chronic pancreatitis, whereas it was overexpressed in pancreatic cancer. Serum analysis using a new enzyme-linked antibody sandwich assay (CAM 17.1/WGA) of patients with chronic pancreatitis, pancreatic cancer or other gastrointestinal cancer and of healthy blood donors revealed a high sensitivity (67%) and excellent specificity (90%) of CAM 17.1/WGA assay in pancreatic cancer. In comparison with the tumour marker CA19-9, the sensitivity of the CAM 17.1/WGA assay was similar to the sensitivity of CA 19-9 (67% and 76%, P = 0.22), whereas the specificity of CAM 17.1/WGA assay was higher than in CA 19-9 (90% compared with 78% in chronic pancreatitis, P > 0.05). IMAGES:
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spelling pubmed-20748162009-09-10 CAM 17.1--a new diagnostic marker in pancreatic cancer. Gansauge, F. Gansauge, S. Parker, N. Beger, M. I. Poch, B. Link, K. H. Safi, F. Beger, H. G. Br J Cancer Research Article CAM 17.1-Ab is a recently described monoclonal antibody that detects a mucus glycoprotein with high specificity for intestinal mucus, particularly in the colon, small intestine, biliary tract and pancreas. We investigated the expression and release of CAM 17.1 in pancreatic carcinoma cell lines and tissue specimens of normal pancreas, chronic pancreatitis and pancreatic cancer. CAM 17.1 was weakly expressed on normal ductal cells and chronic pancreatitis, whereas it was overexpressed in pancreatic cancer. Serum analysis using a new enzyme-linked antibody sandwich assay (CAM 17.1/WGA) of patients with chronic pancreatitis, pancreatic cancer or other gastrointestinal cancer and of healthy blood donors revealed a high sensitivity (67%) and excellent specificity (90%) of CAM 17.1/WGA assay in pancreatic cancer. In comparison with the tumour marker CA19-9, the sensitivity of the CAM 17.1/WGA assay was similar to the sensitivity of CA 19-9 (67% and 76%, P = 0.22), whereas the specificity of CAM 17.1/WGA assay was higher than in CA 19-9 (90% compared with 78% in chronic pancreatitis, P > 0.05). IMAGES: Nature Publishing Group 1996-12 /pmc/articles/PMC2074816/ /pubmed/8980403 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gansauge, F.
Gansauge, S.
Parker, N.
Beger, M. I.
Poch, B.
Link, K. H.
Safi, F.
Beger, H. G.
CAM 17.1--a new diagnostic marker in pancreatic cancer.
title CAM 17.1--a new diagnostic marker in pancreatic cancer.
title_full CAM 17.1--a new diagnostic marker in pancreatic cancer.
title_fullStr CAM 17.1--a new diagnostic marker in pancreatic cancer.
title_full_unstemmed CAM 17.1--a new diagnostic marker in pancreatic cancer.
title_short CAM 17.1--a new diagnostic marker in pancreatic cancer.
title_sort cam 17.1--a new diagnostic marker in pancreatic cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074816/
https://www.ncbi.nlm.nih.gov/pubmed/8980403
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