An increased NM23H1 copy number may be a poor prognostic factor independent of LOH on 1p in neuroblastomas.

In a study of 154 neuroblastomas, loss of heterozygosity (LOH) was observed on 1p (13%, 19/143), 11q (19%, 11/59), 14q (15%, 15/97), 17p (5%, 5/105) and 17q (17%, 9/52). We also found an increase in NM23H1 copy number in 14% (13/95) of neuroblastomas. All except one tumour with an increased copy num...

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Detalles Bibliográficos
Autores principales: Takeda, O., Handa, M., Uehara, T., Maseki, N., Sakashita, A., Sakurai, M., Kanda, N., Arai, Y., Kaneko, Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074847/
https://www.ncbi.nlm.nih.gov/pubmed/8932344

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