Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.

A panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without...

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Autores principales: Munn, K. E., Walker, R. A., Menasce, L., Varley, J. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074864/
https://www.ncbi.nlm.nih.gov/pubmed/8932338
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author Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
author_facet Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
author_sort Munn, K. E.
collection PubMed
description A panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without adjacent invasive or benign cells, have been separately microdissected from paraffin-embedded sections and analysed by PCR for genetic changes to chromosome 17p13. TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones. IMAGES:
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spelling pubmed-20748642009-09-10 Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ. Munn, K. E. Walker, R. A. Menasce, L. Varley, J. M. Br J Cancer Research Article A panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without adjacent invasive or benign cells, have been separately microdissected from paraffin-embedded sections and analysed by PCR for genetic changes to chromosome 17p13. TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones. IMAGES: Nature Publishing Group 1996-11 /pmc/articles/PMC2074864/ /pubmed/8932338 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Munn, K. E.
Walker, R. A.
Menasce, L.
Varley, J. M.
Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title_full Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title_fullStr Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title_full_unstemmed Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title_short Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
title_sort mutation of the tp53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074864/
https://www.ncbi.nlm.nih.gov/pubmed/8932338
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