Cargando…
Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres.
The effect of degradable starch microspheres (DSM) on the intrahepatic distribution of a low molecular weight marker, 99Tcm-labelled methylene diphosphonate (MDP), was studied in rats with hypovascular HSN liver tumours. MDP was injected regionally, via the hepatic artery, alone or co-administered w...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1996
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075812/ https://www.ncbi.nlm.nih.gov/pubmed/8611432 |
_version_ | 1782138084492574720 |
---|---|
author | Chang, D. Jenkins, S. A. Grime, S. J. Nott, D. M. Cooke, T. |
author_facet | Chang, D. Jenkins, S. A. Grime, S. J. Nott, D. M. Cooke, T. |
author_sort | Chang, D. |
collection | PubMed |
description | The effect of degradable starch microspheres (DSM) on the intrahepatic distribution of a low molecular weight marker, 99Tcm-labelled methylene diphosphonate (MDP), was studied in rats with hypovascular HSN liver tumours. MDP was injected regionally, via the hepatic artery, alone or co-administered with DSM, with or without subsequent occlusion of either the hepatic artery or the portal vein. Tumour vascularity was measured with 57Co-labelled microspheres. Co-injection with DSM immediately significantly increased hepatic retention of marker in both tumour (T) (median 22.40 (range 16.82-39.58)% injected dose) and normal liver (N) (9.08 (4.85-12.59) %ID) the greater effect seen in T (P < 0.01). After DSM degradation, very little MDP remained in N (0.61 (0.28-1.40) %ID) but there was significant retention in T (10.01 (6.73-20.28) %ID, P < 0.01). Clamping the hepatic artery had minimal effect on the retention of MDP when administered alone. Regional injection of 16.5 microM 57Co microspheres resulted in a N:T ratio of 2.25:1. Concomitant injection of the 40 microM DSM was 57Co microspheres reversed this ratio to 1:2. The results indicate that DSM selectively enhances the retention of MDP to a hypovascular hepatic tumour, not by causing intra-tumour stasis, but by directing a greater arterial flow to hypovascular areas in the liver. |
format | Text |
id | pubmed-2075812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20758122009-09-10 Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. Chang, D. Jenkins, S. A. Grime, S. J. Nott, D. M. Cooke, T. Br J Cancer Research Article The effect of degradable starch microspheres (DSM) on the intrahepatic distribution of a low molecular weight marker, 99Tcm-labelled methylene diphosphonate (MDP), was studied in rats with hypovascular HSN liver tumours. MDP was injected regionally, via the hepatic artery, alone or co-administered with DSM, with or without subsequent occlusion of either the hepatic artery or the portal vein. Tumour vascularity was measured with 57Co-labelled microspheres. Co-injection with DSM immediately significantly increased hepatic retention of marker in both tumour (T) (median 22.40 (range 16.82-39.58)% injected dose) and normal liver (N) (9.08 (4.85-12.59) %ID) the greater effect seen in T (P < 0.01). After DSM degradation, very little MDP remained in N (0.61 (0.28-1.40) %ID) but there was significant retention in T (10.01 (6.73-20.28) %ID, P < 0.01). Clamping the hepatic artery had minimal effect on the retention of MDP when administered alone. Regional injection of 16.5 microM 57Co microspheres resulted in a N:T ratio of 2.25:1. Concomitant injection of the 40 microM DSM was 57Co microspheres reversed this ratio to 1:2. The results indicate that DSM selectively enhances the retention of MDP to a hypovascular hepatic tumour, not by causing intra-tumour stasis, but by directing a greater arterial flow to hypovascular areas in the liver. Nature Publishing Group 1996-04 /pmc/articles/PMC2075812/ /pubmed/8611432 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Chang, D. Jenkins, S. A. Grime, S. J. Nott, D. M. Cooke, T. Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title | Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title_full | Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title_fullStr | Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title_full_unstemmed | Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title_short | Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
title_sort | increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075812/ https://www.ncbi.nlm.nih.gov/pubmed/8611432 |
work_keys_str_mv | AT changd increasinghepaticarterialflowtohypovascularhepatictumoursusingdegradablestarchmicrospheres AT jenkinssa increasinghepaticarterialflowtohypovascularhepatictumoursusingdegradablestarchmicrospheres AT grimesj increasinghepaticarterialflowtohypovascularhepatictumoursusingdegradablestarchmicrospheres AT nottdm increasinghepaticarterialflowtohypovascularhepatictumoursusingdegradablestarchmicrospheres AT cooket increasinghepaticarterialflowtohypovascularhepatictumoursusingdegradablestarchmicrospheres |