p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma.

Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tum...

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Detalles Bibliográficos
Autores principales: Runnebaum, I. B., Köhler, T., Stickeler, E., Kieback, H. R., Kreienberg, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075926/
https://www.ncbi.nlm.nih.gov/pubmed/8883398
Descripción
Sumario:Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tumours with mutant and wild-type p53 was 25.74% (median) and 12.55% (median) respectively. IMAGES:

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