Sporadic CDKN2 (MTS1/p16ink4) gene alterations in human ovarian tumours.

The cell cycle regulatory proteins p16 and p21 cause cell cycle arrest at the G1 checkpoint by inhibiting activity of cyclin D-CDK4 complexes. The TP53 gene, regulating the p21 protein, is mutated at high frequency in ovarian cancer. The CDKN2 gene, encoding the p16 protein, has been mapped to chrom...

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Detalles Bibliográficos
Autores principales: Schuyer, M., van Staveren, I. L., Klijn, J. G., vd Burg, M. E., Stoter, G., Henzen-Logmans, S. C., Foekens, J. A., Berns, E. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077110/
https://www.ncbi.nlm.nih.gov/pubmed/8855976

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