Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.

We examined 26 gastric carcinomas from British patients for mutations of the APC gene using a single-strand conformation polymorphism (SSCP) and heteroduplex assay in conjunction with the protein truncation test (PTT). In addition, we performed loss of heterozygosity (LOH) analysis of the APC and MC...

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Autores principales: Sud, R., Talbot, I. C., Delhanty, J. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077127/
https://www.ncbi.nlm.nih.gov/pubmed/8855982
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author Sud, R.
Talbot, I. C.
Delhanty, J. D.
author_facet Sud, R.
Talbot, I. C.
Delhanty, J. D.
author_sort Sud, R.
collection PubMed
description We examined 26 gastric carcinomas from British patients for mutations of the APC gene using a single-strand conformation polymorphism (SSCP) and heteroduplex assay in conjunction with the protein truncation test (PTT). In addition, we performed loss of heterozygosity (LOH) analysis of the APC and MCC genes. We detected an inactivating somatic mutation in one gastric tumour. LOH of APC was observed in one of 12 informative cases (8%) and of MCC in two of 20 cases (10%). We thus find that alteration of the APC and MCC genes are infrequent in gastric cancers from the British population. Tumour-suppressor genes on other chromosomes must play a more significant role in the development of these tumours. IMAGES:
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spelling pubmed-20771272009-09-10 Infrequent alterations of the APC and MCC genes in gastric cancers from British patients. Sud, R. Talbot, I. C. Delhanty, J. D. Br J Cancer Research Article We examined 26 gastric carcinomas from British patients for mutations of the APC gene using a single-strand conformation polymorphism (SSCP) and heteroduplex assay in conjunction with the protein truncation test (PTT). In addition, we performed loss of heterozygosity (LOH) analysis of the APC and MCC genes. We detected an inactivating somatic mutation in one gastric tumour. LOH of APC was observed in one of 12 informative cases (8%) and of MCC in two of 20 cases (10%). We thus find that alteration of the APC and MCC genes are infrequent in gastric cancers from the British population. Tumour-suppressor genes on other chromosomes must play a more significant role in the development of these tumours. IMAGES: Nature Publishing Group 1996-10 /pmc/articles/PMC2077127/ /pubmed/8855982 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sud, R.
Talbot, I. C.
Delhanty, J. D.
Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title_full Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title_fullStr Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title_full_unstemmed Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title_short Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
title_sort infrequent alterations of the apc and mcc genes in gastric cancers from british patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077127/
https://www.ncbi.nlm.nih.gov/pubmed/8855982
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