Cargando…

Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination.

This is a study of immune responses generated by mutant ras peptide vaccination of patients with pancreatic adenocarcinoma. Responding T cells from one patient were cloned and two CD4+ T-lymphocyte clones (TLC) specific for the 12 Val peptide and restricted by HLA-DR6 or DQ2 were obtained. These cla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gjertsen, M. K., Saeterdal, I., Thorsby, E., Gaudernack, G.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1996
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077214/ https://www.ncbi.nlm.nih.gov/pubmed/8956801

Ejemplares similares

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
por: Bernhardt, S L, et al.
Publicado: (2006)

Peptides That Block RAS-p21 Protein-Induced Cell Transformation
por: Pincus, Matthew R., et al.
Publicado: (2023)

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α
por: Ismail, Mohamed, et al.
Publicado: (2023)

Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers
por: Shono, Y, et al.
Publicado: (2003)

Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells
por: Schneider, Helga, et al.
Publicado: (2008)

Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
por: Ferguson, Robert, et al.
Publicado: (2023)

Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene
por: Ura, Hitoshi, et al.
Publicado: (1994)

Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors
por: Clavaín, Laura, et al.
Publicado: (2022)

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer
por: Fernández Montes, A., et al.
Publicado: (2022)

The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide
por: Tan, Guang, et al.
Publicado: (2011)

The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model
por: García-Cruz, Roseli, et al.
Publicado: (2015)

ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
Publicado: (1985)

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras
Publicado: (1994)

Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway
Publicado: (1993)

Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer
por: Zhang, Xiaofei, et al.
Publicado: (2022)

BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside expression for therapy of ras-driven tumor
por: Yu, Ting, et al.
Publicado: (2022)

Immunization with nanovaccines containing mutated K-Ras peptides and imiquimod aggravates heterotopic pancreatic cancer induced in mice
por: Martínez-Pérez, Amparo, et al.
Publicado: (2023)

Ras p21 in breast tissue: associations with pathology and cellular localisation.
por: Going, J. J., et al.
Publicado: (1992)

Prognostic significance of ras/p21 alterations in human ovarian cancer.
por: Scambia, G., et al.
Publicado: (1997)

K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
por: Breivik, J., et al.
Publicado: (1994)

Inhibition of human lung cancer cells by anti-p21Ras scFv mediated by the activatable cell-penetrating peptide
por: Du, Yu, et al.
Publicado: (2021)

Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways
por: Padavano, Julianna, et al.
Publicado: (2015)

Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice
por: Salaymeh, Yaser, et al.
Publicado: (2020)

Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition
por: Hamada, Shin, et al.
Publicado: (2021)

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons
Publicado: (1993)

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells
Publicado: (1993)

The effects of mutant Ras proteins on the cell signalome
por: Takács, Tamás, et al.
Publicado: (2020)

K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas
por: Reza, Joseph, et al.
Publicado: (2019)

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
por: Ilter, Metehan, et al.
Publicado: (2022)

Multiple K‐ras Mutations in Hyperplasia and Carcinoma in Cases of Human Pancreatic Carcinoma
por: Matsubayashi, Hiroyuki, et al.
Publicado: (1999)

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide
Publicado: (1994)

Transient Disappearance of RAS Mutant Clones in Plasma: A Counterintuitive Clinical Use of EGFR Inhibitors in RAS Mutant Metastatic Colorectal Cancer
por: Raimondi, Cristina, et al.
Publicado: (2019)

Undetectable RAS-Mutant Clones in Plasma: Possible Implication for Anti-EGFR Therapy and Prognosis in Patients With RAS-Mutant Metastatic Colorectal Cancer
por: Bouchahda, Mohamed, et al.
Publicado: (2020)

Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
por: Shin, Seung-Min, et al.
Publicado: (2020)

Elevated serum RAS p21 is an independent prognostic factor in metastatic breast cancer
por: Banys-Paluchowski, Malgorzata, et al.
Publicado: (2018)

Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer
por: Wang, Yang-Yang, et al.
Publicado: (2022)

Detection of Mutant RAS Subpopulations in Colorectal Cancer Patients
por: Banda, Malathi
Publicado: (2015)

Selective and noncovalent targeting of RAS mutants for inhibition and degradation
por: Teng, Kai Wen, et al.
Publicado: (2021)

Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
por: Scharpf, Robert B., et al.
Publicado: (2022)

Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo
por: Fine, Robert L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_blg3cl9mjhp17ski5l01ev3r1g