Cargando…

Combined effect of clinically relevant doses of emitefur, a new 5-fluorouracil derivative, and radiation in murine tumours.

We investigated the combined effect of radiation and clinically relevant doses of emitefur (BOF-A2), a newly developed anti-cancer agent consisting of a masked form of 5-fluorouracil (5-FU) and a potent inhibitor of 5-FU degradation, in two types of murine tumours. In preliminary pharmacokinetic stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shibamoto, Y., Murata, R., Miyauchi, S., Hirohashi, M., Takagi, T., Sasai, K., Shibata, T., Oya, N., Takahashi, M.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1996
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077217/ https://www.ncbi.nlm.nih.gov/pubmed/8956782

Ejemplares similares

Comparison of in vivo Efficacy of Hypoxic Cytotoxin Tirapazamine and Hypoxic Cell Radiosensitizer KU‐2285 in Combination with Single and Fractionated Irradiation
por: Shibata, Toru, et al.
Publicado: (1996)

Reduction of the radiation dose for intracranial germinoma: a prospective study.
por: Shibamoto, Y., et al.
Publicado: (1994)

Combined effect of buthionine sulfoximine and cyclophosphamide upon murine tumours and bone marrow.
por: Ono, K., et al.
Publicado: (1986)

Changes in Cell Proliferative Parameters of SCCVII and EMT6 Murine Tumors after Single‐dose Irradiation
por: Murata, Rumi, et al.
Publicado: (1996)

Radiation dose for thymic tumours
por: Lalani, Nafisha, et al.
Publicado: (2020)

Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer
por: Miyauchi, Rise, et al.
Publicado: (2017)

A Novel Class of Antitumor Prodrug, 1‐(2′‐Oxopropyl)‐5‐fluorouracil (OFU001), That Releases 5‐Fluorouracil upon Hypoxic Irradiation
por: Shibamoto, Yuta, et al.
Publicado: (2000)

Cinnarizine and flunarizine as radiation sensitisers in two murine tumours.
por: Wood, P. J., et al.
Publicado: (1988)

Assessment of the proliferative activity and radiosensitivity of human tumours using the cytokinesis-block micronucleus assay.
por: Shibamoto, Y., et al.
Publicado: (1994)

Solid tumour models for the assessment of different treatment modalities: IV. the combined effects of radiation and 5-fluorouracil.
por: Looney, W. B., et al.
Publicado: (1976)

Solid Tumour Models for the Assessment of Different Treatment Modalities: VII: Single vs Fractionated Doses of 5-Fluorouracil on Two Solid Tumours and Their Hosts
por: Looney, W. B., et al.
Publicado: (1978)

Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours
por: Turner, N C, et al.
Publicado: (2010)

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model
por: Julien, S, et al.
Publicado: (2009)

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells.
por: Ojugo, A. S., et al.
Publicado: (1998)

Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
por: Siemann, D. W.
Publicado: (1982)

Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
por: Gonzalez, M A, et al.
Publicado: (2003)

FBJ Virus-induced Tumours in Mice: A Histopathological Study of FBJ Virus Tumours and their Relevance to Murine and Human Osteosarcoma Arising in Bone
por: Price, C. H. G., et al.
Publicado: (1972)

Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single doses
por: Iwata, Hiromitsu, et al.
Publicado: (2013)

Relationship between radiation doses to heart substructures and radiation pneumonitis in patients with thymic epithelial tumors
por: Tomita, Natsuo, et al.
Publicado: (2020)

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
por: Peters, G. J., et al.
Publicado: (1989)

Generation of murine tumour-reactive T cells by co-culturing murine pancreatic cancer organoids and peripheral blood lymphocytes
por: D'Angelo, Alberto, et al.
Publicado: (2022)

Gamma radiation at a human relevant low dose rate is genotoxic in mice
por: Graupner, Anne, et al.
Publicado: (2016)

The effects of high dose and highly fractionated radiation on distraction osteogenesis in the murine mandible
por: Monson, Laura A, et al.
Publicado: (2012)

Meta-analysis of non-tumour doses for radiation-induced cancer on the basis of dose-rate
por: Tanooka, Hiroshi
Publicado: (2011)

Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity
por: Corre, Isabelle, et al.
Publicado: (2013)

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma
por: Ide, Hiroki, et al.
Publicado: (2012)

Detection of Hypoxic Cells in Murine Tumors Using the Comet Assay: Comparison with a Conventional Radiobiological Assay
por: Shibuya, Keiko, et al.
Publicado: (1999)

The effect of 5-fluorouracil and alpha interferon and 5-fluorouracil and leucovorin on cellular anti-tumour immune responses in patients with advanced colorectal cancer.
por: Nichols, P. H., et al.
Publicado: (1994)

Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours
por: Haldbo-Classen, L., et al.
Publicado: (2021)

Streptozocin/5-fluorouracil chemotherapy of pancreatic neuroendocrine tumours in the era of targeted therapy
por: Lahner, Harald, et al.
Publicado: (2021)

Radiation Therapy for Primary Central Nervous System Lymphoma
por: Shibamoto, Yuta
Publicado: (2013)

Case of papillary thyroid cancer presenting with an inoperable cervical mass successfully treated with high-dose radiation therapy
por: Kosugi, Yasuo, et al.
Publicado: (2021)

Inhibition of Catabolic Pathway of 5‐Fluorouracil by 3‐Cyano‐2,6‐dihydroxypyridine in Human Lung Cancer Tissues
por: Okayasu, Takeshi, et al.
Publicado: (1994)

Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer
por: Liao, Ai-Ho, et al.
Publicado: (2022)

Fluorouracil Catabolism in the Combination Treatment of Cyclophosphamide, Methotrexate and Fluorouracil
por: De Bruijn, Ernst A., et al.
Publicado: (1992)

Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma
por: Osawa, Satoshi, et al.
Publicado: (2009)

Bolus/infusional 5-fluorouracil and folinic acid. A report on two prospective, consecutive phase II studies with 5-fluorouracil dose escalation.
por: Mackean, M. J., et al.
Publicado: (1998)

Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut
por: Bach, S P, et al.
Publicado: (2006)

Timed flat infusion of 5-fluorouracil increases the tolerability of 5-fluorouracil/docetaxel regimen in metastatic breast cancer: a dose-finding study
por: Ficorella, C, et al.
Publicado: (2004)

Measuring Tumour Imatinib Concentrations in Gastrointestinal Stromal Tumours: Relevant or Redundant?
por: Giraud, Eline L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j9ot281erhss473rfq89jlho33