Cargando…
Fractional anisotropy in white matter tracts of very-low-birth-weight infants
BACKGROUND: Advances in neonatal intensive care have not yet reduced the high incidence of neurodevelopmental disability among very-low-birth-weight (VLBW) infants. As neurological deficits are related to white-matter injury, early detection is important. Diffusion tensor imaging (DTI) could be an e...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077923/ https://www.ncbi.nlm.nih.gov/pubmed/17909782 http://dx.doi.org/10.1007/s00247-007-0626-7 |
_version_ | 1782138127697051648 |
---|---|
author | Dudink, Jeroen Lequin, Maarten van Pul, Carola Buijs, Jan Conneman, Nikk van Goudoever, Johannes Govaert, Paul |
author_facet | Dudink, Jeroen Lequin, Maarten van Pul, Carola Buijs, Jan Conneman, Nikk van Goudoever, Johannes Govaert, Paul |
author_sort | Dudink, Jeroen |
collection | PubMed |
description | BACKGROUND: Advances in neonatal intensive care have not yet reduced the high incidence of neurodevelopmental disability among very-low-birth-weight (VLBW) infants. As neurological deficits are related to white-matter injury, early detection is important. Diffusion tensor imaging (DTI) could be an excellent tool for assessment of white-matter injury. OBJECTIVE: To provide DTI fractional anisotropy (FA) reference values for white-matter tracts of VLBW infants for clinical use. MATERIALS AND METHODS: We retrospectively analysed DTI images of 28 VLBW infants (26–32 weeks gestational age) without evidence of white-matter abnormalities on conventional MRI sequences, and normal developmental outcome (assessed at age 1–3 years). For DTI an echoplanar sequence with diffusion gradient (b = 1,000 s/mm(2)) applied in 25 non-collinear directions was used. We measured FA and apparent diffusion coefficient (ADC) of different white-matter tracts in the first 4 days of life. RESULTS: A statistically significant correlation was found between gestational age and FA of the posterior limb of the internal capsule in VLBW infants (r = 0.495, P<0.01). CONCLUSION: Values of FA and ADC were measured in white-matter tracts of VLBW infants. FA of the pyramidal tracts measured in the first few days after birth is related to gestational age. |
format | Text |
id | pubmed-2077923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-20779232007-11-15 Fractional anisotropy in white matter tracts of very-low-birth-weight infants Dudink, Jeroen Lequin, Maarten van Pul, Carola Buijs, Jan Conneman, Nikk van Goudoever, Johannes Govaert, Paul Pediatr Radiol Original Article BACKGROUND: Advances in neonatal intensive care have not yet reduced the high incidence of neurodevelopmental disability among very-low-birth-weight (VLBW) infants. As neurological deficits are related to white-matter injury, early detection is important. Diffusion tensor imaging (DTI) could be an excellent tool for assessment of white-matter injury. OBJECTIVE: To provide DTI fractional anisotropy (FA) reference values for white-matter tracts of VLBW infants for clinical use. MATERIALS AND METHODS: We retrospectively analysed DTI images of 28 VLBW infants (26–32 weeks gestational age) without evidence of white-matter abnormalities on conventional MRI sequences, and normal developmental outcome (assessed at age 1–3 years). For DTI an echoplanar sequence with diffusion gradient (b = 1,000 s/mm(2)) applied in 25 non-collinear directions was used. We measured FA and apparent diffusion coefficient (ADC) of different white-matter tracts in the first 4 days of life. RESULTS: A statistically significant correlation was found between gestational age and FA of the posterior limb of the internal capsule in VLBW infants (r = 0.495, P<0.01). CONCLUSION: Values of FA and ADC were measured in white-matter tracts of VLBW infants. FA of the pyramidal tracts measured in the first few days after birth is related to gestational age. Springer-Verlag 2007-10-02 2007-12 /pmc/articles/PMC2077923/ /pubmed/17909782 http://dx.doi.org/10.1007/s00247-007-0626-7 Text en © Springer-Verlag 2007 |
spellingShingle | Original Article Dudink, Jeroen Lequin, Maarten van Pul, Carola Buijs, Jan Conneman, Nikk van Goudoever, Johannes Govaert, Paul Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title | Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title_full | Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title_fullStr | Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title_full_unstemmed | Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title_short | Fractional anisotropy in white matter tracts of very-low-birth-weight infants |
title_sort | fractional anisotropy in white matter tracts of very-low-birth-weight infants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077923/ https://www.ncbi.nlm.nih.gov/pubmed/17909782 http://dx.doi.org/10.1007/s00247-007-0626-7 |
work_keys_str_mv | AT dudinkjeroen fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT lequinmaarten fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT vanpulcarola fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT buijsjan fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT connemannikk fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT vangoudoeverjohannes fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants AT govaertpaul fractionalanisotropyinwhitemattertractsofverylowbirthweightinfants |