Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control

Trf4 is the poly(A) polymerase component of TRAMP4, which stimulates nuclear RNA degradation by the exosome. We report that in Saccharomyces cerevisiae strains lacking Trf4, cryptic transcripts are detected from regions of repressed chromatin at telomeres and the rDNA intergenic spacer region (IGS1-...

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Detalles Bibliográficos
Autores principales: Houseley, Jonathan, Kotovic, Kimberly, El Hage, Aziz, Tollervey, David
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080816/
https://www.ncbi.nlm.nih.gov/pubmed/18007593
http://dx.doi.org/10.1038/sj.emboj.7601921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080816/
https://www.ncbi.nlm.nih.gov/pubmed/18007593
http://dx.doi.org/10.1038/sj.emboj.7601921

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