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Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
Trf4 is the poly(A) polymerase component of TRAMP4, which stimulates nuclear RNA degradation by the exosome. We report that in Saccharomyces cerevisiae strains lacking Trf4, cryptic transcripts are detected from regions of repressed chromatin at telomeres and the rDNA intergenic spacer region (IGS1-...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080816/ https://www.ncbi.nlm.nih.gov/pubmed/18007593 http://dx.doi.org/10.1038/sj.emboj.7601921 |