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Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed

Cellular transition to anaphase and mitotic exit has been linked to the loss of cyclin-dependent kinase 1 (Cdk1) kinase activity as a result of anaphase-promoting complex/cyclosome (APC/C)–dependent specific degradation of its cyclin B1 subunit. Cdk1 inhibition by roscovitine is known to induce prem...

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Detalles Bibliográficos
Autores principales:	Skoufias, Dimitrios A., Indorato, Rose-Laure, Lacroix, Françoise, Panopoulos, Andreas, Margolis, Robert L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080905/ https://www.ncbi.nlm.nih.gov/pubmed/18025303 http://dx.doi.org/10.1083/jcb.200704117

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