In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5′ splice sites

We have found that two previously reported exonic mutations in the PINK1 and PARK7 genes affect pre-mRNA splicing. To develop an algorithm to predict underestimated splicing consequences of exonic mutations at the 5′ splice site, we constructed and analyzed 31 minigenes carrying exonic splicing muta...

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Detalles Bibliográficos
Autores principales: Sahashi, Kentaro, Masuda, Akio, Matsuura, Tohru, Shinmi, Jun, Zhang, Zhujun, Takeshima, Yasuhiro, Matsuo, Masafumi, Sobue, Gen, Ohno, Kinji
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094079/
https://www.ncbi.nlm.nih.gov/pubmed/17726045
http://dx.doi.org/10.1093/nar/gkm647

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