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Direct observation of the reversible unwinding of a single DNA molecule caused by the intercalation of ethidium bromide
Ethidium bromide (EtBr) is the conventional intercalator for visualizing DNA. Previous studies suggested that EtBr lengthens and unwinds double-stranded DNA (dsDNA). However, no one has observed the unwinding of a single dsDNA molecule during intercalation. We developed a simple method to observe th...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095801/ https://www.ncbi.nlm.nih.gov/pubmed/17905818 http://dx.doi.org/10.1093/nar/gkm529 |