P2X(7) receptor: Death or life?

The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent...

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Detalles Bibliográficos
Autores principales: Adinolfi, Elena, Pizzirani, Cinzia, Idzko, Marco, Panther, Elisabeth, Norgauer, Johannes, Di Virgilio, Francesco, Ferrari, Davide
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096546/
https://www.ncbi.nlm.nih.gov/pubmed/18404507
http://dx.doi.org/10.1007/s11302-005-6322-x
Descripción
Sumario:The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X(7) function in carcinogenesis.

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