P2Y receptors and pain transmission

It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in pri...

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Detalles Bibliográficos
Autores principales: Gerevich, Zoltan, Illes, Peter
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096565/
https://www.ncbi.nlm.nih.gov/pubmed/18404394
http://dx.doi.org/10.1007/s11302-004-4740-9
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author Gerevich, Zoltan
Illes, Peter
author_facet Gerevich, Zoltan
Illes, Peter
author_sort Gerevich, Zoltan
collection PubMed
description It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y(1) and P2Y(2) receptors are typically expressed in small, nociceptive cells. Here we review the results available on the involvement of P2Y receptors in the modulation of pain transmission.
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spelling pubmed-20965652008-02-27 P2Y receptors and pain transmission Gerevich, Zoltan Illes, Peter Purinergic Signal Review It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y(1) and P2Y(2) receptors are typically expressed in small, nociceptive cells. Here we review the results available on the involvement of P2Y receptors in the modulation of pain transmission. Springer Netherlands 2004-12 /pmc/articles/PMC2096565/ /pubmed/18404394 http://dx.doi.org/10.1007/s11302-004-4740-9 Text en © Springer 2004
spellingShingle Review
Gerevich, Zoltan
Illes, Peter
P2Y receptors and pain transmission
title P2Y receptors and pain transmission
title_full P2Y receptors and pain transmission
title_fullStr P2Y receptors and pain transmission
title_full_unstemmed P2Y receptors and pain transmission
title_short P2Y receptors and pain transmission
title_sort p2y receptors and pain transmission
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096565/
https://www.ncbi.nlm.nih.gov/pubmed/18404394
http://dx.doi.org/10.1007/s11302-004-4740-9
work_keys_str_mv AT gerevichzoltan p2yreceptorsandpaintransmission
AT illespeter p2yreceptorsandpaintransmission

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