Cargando…

Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands

A series of 2-phenylethynyladenosine (PEAdo) derivatives substituted in the N(6)- and 4′position was synthesised and the new derivatives were tested at the four human adenosine receptors stably transfected into Chinese hamster ovary (CHO) cells, using radioligand binding studies (A(1), A(2A), A(3))...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dal Ben, Diego, Lambertucci, Catia, Taffi, Sara, Vittori, Sauro, Volpini, Rosaria, Cristalli, Gloria, Klotz, Karl-Norbert
Formato:	Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096654/ https://www.ncbi.nlm.nih.gov/pubmed/18404461 http://dx.doi.org/10.1007/s11302-006-9010-6

Ejemplares similares

Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands
por: Dal Ben, Diego, et al.
Publicado: (2006)

2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors
por: Volpini, Rosaria, et al.
Publicado: (2005)

New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile
por: Lambertucci, Catia, et al.
Publicado: (2007)

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A(2B) adenosine receptor
por: Dal Ben, Diego, et al.
Publicado: (2013)

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview
por: Dal Ben, Diego, et al.
Publicado: (2019)

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases
por: Dal Ben, Diego, et al.
Publicado: (2018)

P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications
por: Spinaci, Andrea, et al.
Publicado: (2021)

A(2A) Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?
por: Spinaci, Andrea, et al.
Publicado: (2022)

A(3) Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity
por: Spinaci, Andrea, et al.
Publicado: (2022)

Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A(2A) Adenosine Receptor Useful in Neurodegenerative Disorders
por: Francucci, Beatrice, et al.
Publicado: (2023)

Adenosine Receptors as Neuroinflammation Modulators: Role of A(1) Agonists and A(2A) Antagonists
por: Martí Navia, Aleix, et al.
Publicado: (2020)

Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A(1) Receptor Ligands
por: Zuccarini, Mariachiara, et al.
Publicado: (2021)

Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17)
por: Zhuo, Tongyou, et al.
Publicado: (2017)

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A(3) Receptor Agonist, in a Rat Model of Colitis
por: Antonioli, Luca, et al.
Publicado: (2020)

Combined Therapy of A(1)AR Agonists and A(2A)AR Antagonists in Neuroinflammation
por: Marucci, Gabriella, et al.
Publicado: (2021)

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
por: Catarzi, Daniela, et al.
Publicado: (2019)

“Dual Anta-Inhibitors” of the A(2A) Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
por: Spinaci, Andrea, et al.
Publicado: (2023)

4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives
por: Catarzi, Daniela, et al.
Publicado: (2022)

Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs
por: Vazquez-Rodriguez, Saleta, et al.
Publicado: (2020)

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A(2A) adenosine receptor binding site
por: Matricon, Pierre, et al.
Publicado: (2017)

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes
por: Bolcato, Chiara, et al.
Publicado: (2007)

Functional selectivity of adenosine receptor ligands
por: Verzijl, Dennis, et al.
Publicado: (2011)

Evolutionary design of selective adenosine receptor ligands
por: van der Eelke, Horst, et al.
Publicado: (2010)

The possible role of the nucleoside adenosine in countering skin aging: A review
por: Marucci, Gabriella, et al.
Publicado: (2022)

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A(1) and A(2A) Receptors, and Efficacy in Animal Models of Depression
por: Varano, Flavia, et al.
Publicado: (2021)

Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines
por: Buccioni, Michela, et al.
Publicado: (2014)

The A(2B) adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1
por: Koussémou, Marthe, et al.
Publicado: (2018)

Pharmacological characterisation of novel adenosine A(3) receptor antagonists
por: Barkan, Kerry, et al.
Publicado: (2020)

Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors
por: Salmaso, Veronica, et al.
Publicado: (2023)

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors
por: Jespers, Willem, et al.
Publicado: (2017)

Synthesis of adenosine analogues with indole moiety as human adenosine A(3) receptor ligands
por: Xia, Yan, et al.
Publicado: (2018)

Predicting Subtype Selectivity for Adenosine Receptor Ligands with Three-Dimensional Biologically Relevant Spectrum (BRS-3D)
por: He, Song-Bing, et al.
Publicado: (2016)

Fractalkine (CX(3)CL1) enhances hippocampal N-methyl-d-aspartate receptor (NMDAR) function via d-serine and adenosine receptor type A2 (A(2A)R) activity
por: Scianni, Maria, et al.
Publicado: (2013)

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
por: Cacciari, Barbara, et al.
Publicado: (2006)

Publisher Correction: Predicting Subtype Selectivity for Adenosine Receptor Ligands with Three-Dimensional Biologically Relevant Spectrum (BRS-3D)
por: He, Song-Bing, et al.
Publicado: (2021)

Structure-Based Discovery of A(2A) Adenosine Receptor Ligands
por: Carlsson, Jens, et al.
Publicado: (2010)

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
por: Geldenhuys, Werner J., et al.
Publicado: (2017)

Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A(1) Adenosine Receptor Antagonists
por: Kolb, Peter, et al.
Publicado: (2012)

Therapeutic Potential of Highly Selective A(3) Adenosine Receptor Ligands in the Central and Peripheral Nervous System
por: Coppi, Elisabetta, et al.
Publicado: (2022)

Computational Elucidation of Structural Basis for Ligand Binding with Leishmania donovani Adenosine Kinase
por: Kar, Rajiv K., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_dniar5rq4hi5v5lvhk4caevtn3