Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor

Downstream A(3) receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A(3) receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated pro...

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Detalles Bibliográficos
Autores principales: Merighi, Stefania, Benini, Annalisa, Mirandola, Prisco, Gessi, Stefania, Varani, Katia, Leung, Edward, MacLennan, Stephen, Baraldi, Pier Giovanni, Borea, Pier Andrea
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096659/
https://www.ncbi.nlm.nih.gov/pubmed/18404465
http://dx.doi.org/10.1007/s11302-006-9020-4
Descripción
Sumario:Downstream A(3) receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A(3) receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A(3) adenosine receptor signalling.

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