Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor

Downstream A(3) receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A(3) receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated pro...

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Autores principales: Merighi, Stefania, Benini, Annalisa, Mirandola, Prisco, Gessi, Stefania, Varani, Katia, Leung, Edward, MacLennan, Stephen, Baraldi, Pier Giovanni, Borea, Pier Andrea
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096659/
https://www.ncbi.nlm.nih.gov/pubmed/18404465
http://dx.doi.org/10.1007/s11302-006-9020-4
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author Merighi, Stefania
Benini, Annalisa
Mirandola, Prisco
Gessi, Stefania
Varani, Katia
Leung, Edward
MacLennan, Stephen
Baraldi, Pier Giovanni
Borea, Pier Andrea
author_facet Merighi, Stefania
Benini, Annalisa
Mirandola, Prisco
Gessi, Stefania
Varani, Katia
Leung, Edward
MacLennan, Stephen
Baraldi, Pier Giovanni
Borea, Pier Andrea
author_sort Merighi, Stefania
collection PubMed
description Downstream A(3) receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A(3) receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A(3) adenosine receptor signalling.
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spelling pubmed-20966592008-02-27 Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor Merighi, Stefania Benini, Annalisa Mirandola, Prisco Gessi, Stefania Varani, Katia Leung, Edward MacLennan, Stephen Baraldi, Pier Giovanni Borea, Pier Andrea Purinergic Signal Article Downstream A(3) receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A(3) receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A(3) adenosine receptor signalling. Springer Netherlands 2006-07-26 2006-11 /pmc/articles/PMC2096659/ /pubmed/18404465 http://dx.doi.org/10.1007/s11302-006-9020-4 Text en © Springer Science + Business Media B.V. 2006
spellingShingle Article
Merighi, Stefania
Benini, Annalisa
Mirandola, Prisco
Gessi, Stefania
Varani, Katia
Leung, Edward
MacLennan, Stephen
Baraldi, Pier Giovanni
Borea, Pier Andrea
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title_full Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title_fullStr Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title_full_unstemmed Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title_short Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
title_sort modulation of the akt/ras/raf/mek/erk pathway by a(3) adenosine receptor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096659/
https://www.ncbi.nlm.nih.gov/pubmed/18404465
http://dx.doi.org/10.1007/s11302-006-9020-4
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