The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family

The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), L...

Descripción completa

Detalles Bibliográficos
Autores principales: Reimers, Kerstin, Choi, Claudia YU, Bucan, Vesna, Vogt, Peter M
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2007
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096737/
https://www.ncbi.nlm.nih.gov/pubmed/18071587
_version_ 1782138263008444416
author Reimers, Kerstin
Choi, Claudia YU
Bucan, Vesna
Vogt, Peter M
author_facet Reimers, Kerstin
Choi, Claudia YU
Bucan, Vesna
Vogt, Peter M
author_sort Reimers, Kerstin
collection PubMed
description The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties.
format Text
id pubmed-2096737
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-20967372007-12-10 The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family Reimers, Kerstin Choi, Claudia YU Bucan, Vesna Vogt, Peter M Int J Biol Sci Research Paper The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties. Ivyspring International Publisher 2007-11-22 /pmc/articles/PMC2096737/ /pubmed/18071587 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Reimers, Kerstin
Choi, Claudia YU
Bucan, Vesna
Vogt, Peter M
The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title_full The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title_fullStr The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title_full_unstemmed The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title_short The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
title_sort growth-hormone inducible transmembrane protein (ghitm) belongs to the bax inhibitory protein-like family
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096737/
https://www.ncbi.nlm.nih.gov/pubmed/18071587
work_keys_str_mv AT reimerskerstin thegrowthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT choiclaudiayu thegrowthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT bucanvesna thegrowthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT vogtpeterm thegrowthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT reimerskerstin growthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT choiclaudiayu growthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT bucanvesna growthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily
AT vogtpeterm growthhormoneinducibletransmembraneproteinghitmbelongstothebaxinhibitoryproteinlikefamily

Ejemplares similares