P2 receptors in macrophage fusion and osteoclast formation

Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X(7), are involved in this process, although P2X(7) is not absolutely required for fusion because P2X(7)-null mice form multinuclea...

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Detalles Bibliográficos
Autores principales: Steinberg, Thomas H., Hiken, Jeffrey F.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2007
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096767/
https://www.ncbi.nlm.nih.gov/pubmed/18404418
http://dx.doi.org/10.1007/s11302-006-9036-9
Descripción
Sumario:Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X(7), are involved in this process, although P2X(7) is not absolutely required for fusion because P2X(7)-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.

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