P2 receptors in macrophage fusion and osteoclast formation

Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X(7), are involved in this process, although P2X(7) is not absolutely required for fusion because P2X(7)-null mice form multinuclea...

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Detalles Bibliográficos
Autores principales: Steinberg, Thomas H., Hiken, Jeffrey F.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2007
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096767/
https://www.ncbi.nlm.nih.gov/pubmed/18404418
http://dx.doi.org/10.1007/s11302-006-9036-9
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author Steinberg, Thomas H.
Hiken, Jeffrey F.
author_facet Steinberg, Thomas H.
Hiken, Jeffrey F.
author_sort Steinberg, Thomas H.
collection PubMed
description Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X(7), are involved in this process, although P2X(7) is not absolutely required for fusion because P2X(7)-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.
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spelling pubmed-20967672008-02-27 P2 receptors in macrophage fusion and osteoclast formation Steinberg, Thomas H. Hiken, Jeffrey F. Purinergic Signal Original Paper Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X(7), are involved in this process, although P2X(7) is not absolutely required for fusion because P2X(7)-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion. Springer Netherlands 2007-02-06 2007-03 /pmc/articles/PMC2096767/ /pubmed/18404418 http://dx.doi.org/10.1007/s11302-006-9036-9 Text en © Springer Science + Business Media B.V. 2007
spellingShingle Original Paper
Steinberg, Thomas H.
Hiken, Jeffrey F.
P2 receptors in macrophage fusion and osteoclast formation
title P2 receptors in macrophage fusion and osteoclast formation
title_full P2 receptors in macrophage fusion and osteoclast formation
title_fullStr P2 receptors in macrophage fusion and osteoclast formation
title_full_unstemmed P2 receptors in macrophage fusion and osteoclast formation
title_short P2 receptors in macrophage fusion and osteoclast formation
title_sort p2 receptors in macrophage fusion and osteoclast formation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096767/
https://www.ncbi.nlm.nih.gov/pubmed/18404418
http://dx.doi.org/10.1007/s11302-006-9036-9
work_keys_str_mv AT steinbergthomash p2receptorsinmacrophagefusionandosteoclastformation
AT hikenjeffreyf p2receptorsinmacrophagefusionandosteoclastformation

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