Biogenesis of γ-secretase early in the secretory pathway

γ-Secretase is responsible for proteolytic maturation of signaling and cell surface proteins, including amyloid precursor protein (APP). Abnormal processing of APP by γ-secretase produces a fragment, Aβ(42), that may be responsible for Alzheimer's disease (AD). The biogenesis and trafficking of...

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Detalles Bibliográficos
Autores principales: Kim, Jinoh, Kleizen, Bertrand, Choy, Regina, Thinakaran, Gopal, Sisodia, Sangram S., Schekman, Randy W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099203/
https://www.ncbi.nlm.nih.gov/pubmed/18056412
http://dx.doi.org/10.1083/jcb.200709012

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