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Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA
Alternative lengthening of telomere (ALT) tumors maintain telomeres by a telomerase-independent mechanism and are characterized by a nuclear structure called the ALT-associated PML body (APB). TRF2 is a component of a telomeric DNA/protein complex called shelterin. However, TRF2 function in ALT cell...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099206/ https://www.ncbi.nlm.nih.gov/pubmed/18056407 http://dx.doi.org/10.1083/jcb.200703020 |