Cargando…
Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
BACKGROUND: Comfrey (Symphytum officinale) is a perennial plant and has been consumed by humans as a vegetable, a tea and an herbal medicine for more than 2000 years. It, however, is hepatotoxic and carcinogenic in experimental animals and hepatotoxic in humans. Pyrrolizidine alkaloids (PAs) exist i...
Autores principales: | Guo, Lei, Mei, Nan, Dial, Stacey, Fuscoe, James, Chen, Tao |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099491/ https://www.ncbi.nlm.nih.gov/pubmed/18047722 http://dx.doi.org/10.1186/1471-2105-8-S7-S22 |
Ejemplares similares
-
Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
por: Mei, Nan, et al.
Publicado: (2007) -
Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
por: Mei, Nan, et al.
Publicado: (2006) -
Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats
por: Chen, Tao, et al.
Publicado: (2006) -
Mutagenicity of comfrey (Symphytum Officinale) in rat liver
por: Mei, N, et al.
Publicado: (2005) -
Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent
por: Widjaja, Frances, et al.
Publicado: (2021)