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N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance

BACKGROUND: The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date map to the polymerase...

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Detalles Bibliográficos
Autores principales:	Yap, Soo-Huey, Sheen, Chih-Wei, Fahey, Jonathan, Zanin, Mark, Tyssen, David, Lima, Viviane Dias, Wynhoven, Brian, Kuiper, Michael, Sluis-Cremer, Nicolas, Harrigan, P. Richard, Tachedjian, Gilda
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100143/ https://www.ncbi.nlm.nih.gov/pubmed/18052601 http://dx.doi.org/10.1371/journal.pmed.0040335

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